This section covers the ingredients found in Inflame & Pain Relief™ and discusses WHY & HOW they work, including links to clinical and scientific studies. You can also see "recommended use" instructions.
Under the "Supplement Facts", you'll see a list of the specific ingredients and a short overview and description for each.
|Ingredients||Amount Per Serving||%DV*|
|IPR Synergy Optimizer™ Blend||3000 MG||†|
|Turmeric/Curcumin (95% Extract, Tetrahydrocurcuminoids)
(Blend of Curcumin C3 Complex® / C3 Reduct® / BCM-95® Bio-Curcumin®)
|Ginger Extract (Orgainc; 5% gingerols)||200 MG|
|AprèsFlex® Boswellia Serrata (65% extract)||240 MG|
|Green Tea Extract (Theaflavin) (98% poly, 50% EGCG)||400 MG|
|White Willow Bark (salicin) 25% salicylic acid||200 MG|
|Pycnogenol® (pine bark extract; 97% Extract; 65% procyanidins)||200 MG|
|Astragin® Astragalus||100 MG|
|Trans-Resveratrol (50% Extract; Japanese knotweed)||280 MG|
|Uncaria Tomentosa (cat’s claw; 10:1 concentration; 2.3% pentacyclic oxindole alkaloids)||100 MG|
|Quercetin Phytosome||200 MG|
|PARACTIN® Andrographis 10:1||280 MG|
Below you'll find detailed descriptions about the ingredients utilized in Inflame & Pain Relief™ - exactly HOW it works & WHY it's better than other products. Simply click on the ingredients below and a detailed description will appear under it.
Curcumin is the amazing active compound that is found within the turmeric root. It may be one of the most unique nutritional supplements in existence, IF you take the correct, absorbable form (more on that in a minute).
As great as these benefits are, the biggest problem with Turmeric/Curcumin is that it's poorly absorbed.
Which means, if you don't utilize the correct form and dose, you won't get the positive benefits and you'll just be wasting time and money.
Almost all Curcumin extracts (even those with a minimum 95% extract) are only 50% absorbed. So you'll have to take more than double the amount to get the optimal benefits.
This is why we've utilized the 3 most potent and highest absorbable Curcumin extracts - Patented & Scientifically Proven.
Curcumin C3 Reduct® (standardized min 95% tetra-hydro curcuminoids ) - One of the most active forms of Curcumin with 95% tetra-hydro curcuminoids, which is pre-converted and goes to work immediately.
Curcumin C3 Complex® (standardized min 95% total curcuminoids) - Is a patented and scientifically evaluated “Bioprotectant” composition of three Curcuminoids [Curcumin, Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC)]. It's the most studied and validated Curcumin extract on the market. This is more of a slow-release form, over 12 hours.
BCM-95® Bio-Curcumin® - Is validated to have a 97% absorption rate and almost 9x higher bioavailability in the blood.. The end result is high blood concentrations, in less time. Thus, the positive effects are felt faster at an even lower dose, extended over 8 hours.
Ginger contains numerous beneficial compounds, including gingerols, which have free-radical scavenging and healthy inflammatory properties.17
Leukotrienes contribute to dangerous inflammatory reactions. Specific compounds in ginger have been found to inhibit enzymes that produce leukotrienes.18,19
Ginger also works to reduce inflammation by affecting several other compounds and cellular pathways, including:
One of the problems with aging is higher levels of 5-LOX. 5-lipoxygenase (5-LOX) is a member of the lipoxygenase family of enzymes. Excess levels of the enzyme 5-LOX cause inflammatory responses that have been linked to common effects in aging individuals (such as joint pain).
Unfortunately, the typical diet most people eat these days, causes an over production of the 5-LOX enzyme. This further increases pro-inflammatory compounds, which attacks the joints (& soft tissue), arterial walls (poor blood flow), skin (wrinkles), hair (balding) and other tissue.
The good news is that an extract of the Indian plant Boswellia serrata has been shown to help neutralize 5-LOX.
Used for centuries to help with inflammatory factors, Boswellia acts as a natural 5-LOX inhibitor, intervening at the cellular level to block its unwanted negative effects. Clinical studies reveal that a compound contained in Boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)23,24 is the key to its beneficial action.
The problem is that Boswellia is poorly absorbed into the blood.25 Because of this, Inflame & Pain Relief™ utilizes a patented, standardized form of Boswellia called AprèsFlex®. AprèsFlex® absorbs into the blood 52% more than other forms of Boswellia extracts.25
Green tea extract has numerous health benefits, one of them being the powerful anti-inflammatory effects due to the Theaflavin, polyphenols and EGCG.
White willow bark is known as "nature's aspirin" and has been used for centuries as a pain reliever and anti-inflammatory.26 The active ingredient that causes the benefits of willow bark is salicin. Inflame & Pain Relief™ uses the highest extract, at 25% salicylic acid. This means a lower dose is required, but resulting in more positive benefits.
Over 40 years of research and 400 scientific studies have confirmed what our ancestors long suspected, Pycnogenol (a patented pine bark extract) has incredible and numerous health benefits.
Pycnogenol is a powerful anti-inflammatory, anti-oxidant, and anti-histamine, which helps:
In addition, pine bark extract has benefits for skin care, eye care, respiratory function, and women’s health.
It has a positive effect on cognitive health and memory.
As many health benefits Pycnogenol has, I want to focus on joint pain and inflammation. The cushioning cartilage in your joints become damaged through wear and tear which causes inflammation and pain. This happens even faster for those that exercise.
Pycnogenol can ease these symptoms as it is a powerful anti-inflammatory. Studies have shown that taking 30 - 150 mg Pycnogenol daily helps support the mobility and flexibility of joints and helps reduce aches and pains.27-29
Pycnogenol® fights inflammation by switching off a central inflammation-generating system and reducing the production of inflammatory cytokine molecules.29-31
Astragin® is a patented form of Astragalus, with over 25 clinical studies. Astragalus is from one of the most powerful immune-building plants on the planet.
It's an "adaptogen", which means it activates when you're under stress to lower cortisol levels, to help reduce inflammation. Additionally, it helps increase the absorption of other nutrients by 92%. 32
Astragalus works by suppressing NF-kB and AP-1 signaling pathways, which causes inflammation.
Best known as a compound found in red grapes and red wine, resveratrol helps promote and maintain optimal health and longevity.34 Inflame & Pain Relief™ contains trans-resveratrol, the form abundant in red wine, which is well-absorbed and stable.35,36
Resveratrol also promotes healthy insulin sensitivity, encourages enhanced mitochondrial function, supports a healthy inflammatory response, and has demonstrated beneficial cardiovascular activity.37-39
Aside from its indirect antioxidant effects on inflammation, resveratrol also affects very specific inflammatory processes. For one, it can help block inflammatory COX enzymes, which are also the main target of commonly used painkillers and anti-inflammatory drugs.40
However, its effects run much deeper than these conventionally targeted enzymes. Resveratrol also helps reduce the following key anti-inflammatory factors::
Quercetin is a bioflavonoid that supports healthy immune function and optimal inflammatory response.46,47
One of the primary ways quercetin works, is by helping to block important inflammatory substances and pathways (including COX-2 and CRP), similar to NSAID drugs (but without the negatives).
It also blocks the production of prostaglandins, one of the key mediators of the inflammatory response.48,49
Inflame & Pain Relief™ provides quercetin encased in a plant-derived phytosome delivery system, which makes absorption easier: the quercetin in our formula is up to 50 times more bioavailable than a dose of standard quercetin.46,47
And as stated above, there's a special synergy between Quercetin when combined with Resveratrol. These two, especially when combined with the other ingredients in Inflame & Pain Relief™, promotes more potent anti-inflammatory benefits.
Cat’s claw is rich in three major groups of chemical compounds: alkaloids, terpenoids, and flavonoids. It works by supporting and:
ParActin™ is a patented standardized natural extract of Andrographis Paniculata, scientifically proven to help promote healthy inflammatory response and support healthy brain and joint function by naturally invigorating the PPAR gamma receptor, reducing pro-inflammatory cytokines that cause pain and redness from everyday activities.
We've used a patented blend of these andrographolides helps suppress damaging inflammatory cytokines and eases symptomatic discomfort associated with joint pain, stiffness and swelling.60-62