This section covers the ingredients found in Inflame & Pain Relief™ and discusses WHY & HOW they work, including links to clinical and scientific studies. You can also see "recommended use" instructions.
Under the "Supplement Facts", you'll see a list of the specific ingredients and a short overview and description for each.
30 Day Supply
| Ingredients | Amount Per Serving | %DV* |
| IPR Synergy Optimizer™ Blend | 3000 MG | † |
| Turmeric/Curcumin (95% Extract, Tetrahydrocurcuminoids) (Blend of Curcumin C3 Complex® / C3 Reduct® / BCM-95® Bio-Curcumin®) |
800 MG | |
| Ginger Extract (Orgainc; 5% gingerols) | 200 MG | |
| AprèsFlex® Boswellia Serrata (65% extract) | 240 MG | |
| Green Tea Extract (Theaflavin) (98% poly, 50% EGCG) | 400 MG | |
| White Willow Bark (salicin) 25% salicylic acid | 200 MG | |
| Pycnogenol® (pine bark extract; 97% Extract; 65% procyanidins) | 200 MG | |
| Astragin® Astragalus | 100 MG | |
| Trans-Resveratrol (50% Extract; Japanese knotweed) | 280 MG | |
| Uncaria Tomentosa (cat’s claw; 10:1 concentration; 2.3% pentacyclic oxindole alkaloids) | 100 MG | |
| Quercetin Phytosome | 200 MG | |
| PARACTIN® Andrographis 10:1 | 280 MG |
* Percent Daily Values are based on a 2,000 calorie diet.
Other Ingredients: plant-derived vegetable cellulose, (Vegetarian capsule), Rice Flour
Does NOT Contain Any: Artificial colors, wheat, gluten, dairy, egg, fish, peanuts.
Potential Side Effects: There are no known side effects associated with this product. Some have report stomach discomfort when taken on an empty stomach. However, as with any food or supplement product, there may be infrequent and unusual highly sensitized reactions associated with this or any other nutritional supplement. If such a reaction occurs, you should consider discontinuing use of this or any product.
Warnings & Interactions: If you are pregnant, lactating, trying to conceive, under the age of 18, or taking medications (Coumadin®, heparin or any other blood-thinning medication), consult your health care practitioner before using this or any new nutritional product. Do not take this product if you're allergic to aspirin because it contains White Willow Extract (25% Salicin), which is a natural, herbal form of aspirin.
C3 Reduct® is a registered trademark of Sabinsa Corporation
Curcumin C3 Complex® is a registered trademark of Albion Laboratories, Inc.
Astragin® Astragalus is a registered trademark NuLivScience
PARACTIN® is a registered trademark of HP Ingredients.
Capsule Size: Capsules may always be opened and the contents poured into your mouth or a liquid beverage.
Ingredient Summaries:
Below you'll find detailed descriptions about the ingredients utilized in Inflame & Pain Relief™ - exactly HOW it works & WHY it's better than other products. Simply click on the ingredients below and a detailed description will appear under it.
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Turmeric/Curcumin (95% Extract)
Curcumin is the amazing active compound that is found within the turmeric root. It may be one of the most unique nutritional supplements in existence, IF you take the correct, absorbable form (more on that in a minute).
My Top 5 Curcumin Benefits
- Healthy Inflammatory Response: Scientists now believe that chronic, low-level inflammation plays a major role in most health ailments, from head to toe. Your mind, heart, joints, muscles, eyes, lungs, skin, hair, etc.1-6
- Powerful Antioxidant: It helps neutralize free radical damage, that may accelerate aging.7 Additionally, it also helps boost the body's own antioxidant enzymes.8
- Improves Brain Function: It helps increase brain-derived neurotrophic factor (BDNF), which helps preserver youthful brain function..9,10,14
- Heart Health: Curcumin's benefits has been shown to help lower the risk of heart problems associated with inflammation.11-13
- Healthy Immune Function: Helps support healthy immune system response & function.15,16
WARNING - The Major Problem With Curcumin
As great as these benefits are, the biggest problem with Turmeric/Curcumin is that it's poorly absorbed.
Which means, if you don't utilize the correct form and dose, you won't get the positive benefits and you'll just be wasting time and money.
Almost all Curcumin extracts (even those with a minimum 95% extract) are only 50% absorbed. So you'll have to take more than double the amount to get the optimal benefits.
3 Most Potent, Highest Absorbable & Scientifically Validated Forms Of Curcumin
This is why we've utilized the 3 most potent and highest absorbable Curcumin extracts - Patented & Scientifically Proven.
Curcumin C3 Reduct® (standardized min 95% tetra-hydro curcuminoids ) - One of the most active forms of Curcumin with 95% tetra-hydro curcuminoids, which is pre-converted and goes to work immediately.
Curcumin C3 Complex® (standardized min 95% total curcuminoids) - Is a patented and scientifically evaluated “Bioprotectant” composition of three Curcuminoids [Curcumin, Demethoxycurcumin (DMC) and Bisdemethoxycurcumin (BDMC)]. It's the most studied and validated Curcumin extract on the market. This is more of a slow-release form, over 12 hours.
BCM-95® Bio-Curcumin® - Is validated to have a 97% absorption rate and almost 9x higher bioavailability in the blood.. The end result is high blood concentrations, in less time. Thus, the positive effects are felt faster at an even lower dose, extended over 8 hours.
IMPORTANT NOTE: Two things to remember here:
[1] You want to make sure that you ONLY use the highest extract of min 95% because Curcumin isn't absorbed well.
[2] Use only the scientifically researched, most highly absorbable forms which is a combination of Curcumin C3 Reduct®, Curcumin C3 Complex® and BCM-95® Bio-Curcumin® -
Organic Ginger Extract (5% gingerols)
Ginger contains numerous beneficial compounds, including gingerols, which have free-radical scavenging and healthy inflammatory properties.17
Leukotrienes contribute to dangerous inflammatory reactions. Specific compounds in ginger have been found to inhibit enzymes that produce leukotrienes.18,19
Ginger also works to reduce inflammation by affecting several other compounds and cellular pathways, including:
- Reduction in levels of inflammatory mediators, such as tumor necrosis factor-alpha, C-reactive protein, interleukin-1b and interleukin-6.20-22
- Inhibition of nuclear factor kappa B (NF-kB) pathways, which are involved in the initiation of chronic inflammation.20-22
IMPORTANT NOTE: As with most ingredients, absorbability is a major issue. Unfortunately, most ginger is heat processed using high-heat methods, which destroys almost all the benefits. However, Inflame & Pain Relief™ Ginger is naturally dried and not subjected to additional heat. This process ensures the presence of active compounds that are beneficial to the gastrointestinal tract, resulting in maximum benefits. -
AprèsFlex® Boswellia Serrata (65% extract)
One of the problems with aging is higher levels of 5-LOX. 5-lipoxygenase (5-LOX) is a member of the lipoxygenase family of enzymes. Excess levels of the enzyme 5-LOX cause inflammatory responses that have been linked to common effects in aging individuals (such as joint pain).
Unfortunately, the typical diet most people eat these days, causes an over production of the 5-LOX enzyme. This further increases pro-inflammatory compounds, which attacks the joints (& soft tissue), arterial walls (poor blood flow), skin (wrinkles), hair (balding) and other tissue.
The good news is that an extract of the Indian plant Boswellia serrata has been shown to help neutralize 5-LOX.
Used for centuries to help with inflammatory factors, Boswellia acts as a natural 5-LOX inhibitor, intervening at the cellular level to block its unwanted negative effects. Clinical studies reveal that a compound contained in Boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid)23,24 is the key to its beneficial action.
The problem is that Boswellia is poorly absorbed into the blood.25 Because of this, Inflame & Pain Relief™ utilizes a patented, standardized form of Boswellia called AprèsFlex®. AprèsFlex® absorbs into the blood 52% more than other forms of Boswellia extracts.25
IMPORTANT NOTE: Once again, absorbability and bioavailability of ingredients is what counts the most. This is why we use a 65% extract and the special form of AprèsFlex®, which is absorbed 52% better than other Boswellia Serrata products on the market. NEVER purchase the "root", always the extract! -
Green Tea Extract (Theaflavin) (98% poly, 50% EGCG)
Green tea extract has numerous health benefits, one of them being the powerful anti-inflammatory effects due to the Theaflavin, polyphenols and EGCG.
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White Willow Bark (salicin) 25% salicylic acid
White willow bark is known as "nature's aspirin" and has been used for centuries as a pain reliever and anti-inflammatory.26 The active ingredient that causes the benefits of willow bark is salicin. Inflame & Pain Relief™ uses the highest extract, at 25% salicylic acid. This means a lower dose is required, but resulting in more positive benefits.
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Pycnogenol® (97% Extract)
Over 40 years of research and 400 scientific studies have confirmed what our ancestors long suspected, Pycnogenol (a patented pine bark extract) has incredible and numerous health benefits.
Pycnogenol is a powerful anti-inflammatory, anti-oxidant, and anti-histamine, which helps:
- supports healthy blood flow and circulation by strengthening the walls of your blood vessels and capillaries
- promotes flexible joints by reducing inflammation
- fights the free-radicals that cause illnesses
In addition, pine bark extract has benefits for skin care, eye care, respiratory function, and women’s health.
It has a positive effect on cognitive health and memory.
Joint Pain & Inflammation
As many health benefits Pycnogenol has, I want to focus on joint pain and inflammation. The cushioning cartilage in your joints become damaged through wear and tear which causes inflammation and pain. This happens even faster for those that exercise.
Pycnogenol can ease these symptoms as it is a powerful anti-inflammatory. Studies have shown that taking 30 - 150 mg Pycnogenol daily helps support the mobility and flexibility of joints and helps reduce aches and pains.27-29
Pycnogenol® fights inflammation by switching off a central inflammation-generating system and reducing the production of inflammatory cytokine molecules.29-31
IMPORTANT NOTE: This is one of my favorite supplements because it has so many health benefits. The minimum daily dose for joint health and anti-inflammation is 100 mg, with the correct optimal and clinical dose being 200 mg daily -- which is the exact dose in Inflame & Pain Relief™. It's also important to point out that we use a 97% extract. Most companies use "dead" root or 50% of less. Thus, with Inflame & Pain Relief™ you're getting the optimal dose at the best value! -
Astragin® Astragalus
Astragin® is a patented form of Astragalus, with over 25 clinical studies. Astragalus is from one of the most powerful immune-building plants on the planet.
It's an "adaptogen", which means it activates when you're under stress to lower cortisol levels, to help reduce inflammation. Additionally, it helps increase the absorption of other nutrients by 92%. 32
Astragalus works by suppressing NF-kB and AP-1 signaling pathways, which causes inflammation.
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Trans-Resveratrol (50% Extract)
Best known as a compound found in red grapes and red wine, resveratrol helps promote and maintain optimal health and longevity.34 Inflame & Pain Relief™ contains trans-resveratrol, the form abundant in red wine, which is well-absorbed and stable.35,36
Resveratrol also promotes healthy insulin sensitivity, encourages enhanced mitochondrial function, supports a healthy inflammatory response, and has demonstrated beneficial cardiovascular activity.37-39
Potent Anti-Inflammatory
Aside from its indirect antioxidant effects on inflammation, resveratrol also affects very specific inflammatory processes. For one, it can help block inflammatory COX enzymes, which are also the main target of commonly used painkillers and anti-inflammatory drugs.40
However, its effects run much deeper than these conventionally targeted enzymes. Resveratrol also helps reduce the following key anti-inflammatory factors::
- NF-kB pathway, one of the most important and deeply rooted triggers of inflammation in the body.41
- HMGB1, a protein made by immune cells that causes inflammation and tissue damage.42
- STAT3, which contributes to problems in most people with constant inflammation.43
IMPORTANT NOTE: The one problem with Resveratrol is that it's absorbed poorly. Thus, the most absorbable form is the "trans" version, which is what Inflame & Pain Relief™ uses.
Additionally, numerous studies have shown that combining Resveratrol with Quercetin, creates a special synergy - improving absorption, enhancing benefits and further reducing inflammation.43-45 Which is why we've also added Quercetin into the formula (see below). -
Quercetin Phytosome
Quercetin is a bioflavonoid that supports healthy immune function and optimal inflammatory response.46,47
One of the primary ways quercetin works, is by helping to block important inflammatory substances and pathways (including COX-2 and CRP), similar to NSAID drugs (but without the negatives).
It also blocks the production of prostaglandins, one of the key mediators of the inflammatory response.48,49
Inflame & Pain Relief™ provides quercetin encased in a plant-derived phytosome delivery system, which makes absorption easier: the quercetin in our formula is up to 50 times more bioavailable than a dose of standard quercetin.46,47
And as stated above, there's a special synergy between Quercetin when combined with Resveratrol. These two, especially when combined with the other ingredients in Inflame & Pain Relief™, promotes more potent anti-inflammatory benefits.
IMPORTANT NOTE: I've been taking Quercetin for years. It's a fantastic ingredient, almost as great as Curcumin extract.
However, the problem with both is the poor absorbability factor. This is why Inflame & Pain Relief™ uses the phytosome version, which is up to 50x more bioavailable. Why waste your time and money using other products? -
Uncaria Tomentosa (cat’s claw extract; 2.3% pentacyclic oxindole alkaloids)
Cat’s claw is rich in three major groups of chemical compounds: alkaloids, terpenoids, and flavonoids. It works by supporting and:
- Decreasing inflammatory molecules TNF-α and NF-κB.50-52
- Reducing the release of iNos, an enzyme that creates free radicals as part of the immune response, which causes inflammation.53
- Lowering the release of COX-1 and COX-2, enzymes that play crucial roles in inflammation and pain.54,55
IMPORTANT NOTE: You do NOT want to use the "bark" or "root" forms, because they are basically "dead" and do NOT contain any of the active alkaloids (pentacyclic oxindole (POA) and harpagoside). Also, you want it to be free of and WITHOUT the tetracylic oxindole alkaloids (TOA) -
PARACTIN® Andrographis 10:1
ParActin™ is a patented standardized natural extract of Andrographis Paniculata, scientifically proven to help promote healthy inflammatory response and support healthy brain and joint function by naturally invigorating the PPAR gamma receptor, reducing pro-inflammatory cytokines that cause pain and redness from everyday activities.
We've used a patented blend of these andrographolides helps suppress damaging inflammatory cytokines and eases symptomatic discomfort associated with joint pain, stiffness and swelling.60-62